Quantitative Modeling and Simulation of Reaction-diffusion Processes

The project is about finding a description of how slow diffusion in combination with stochastics relates to the sensitivity in intracellular signaltransduction, understanding the dynamics of specific and nonspecific transcription factor binding to DNA at an atomic level and finally investigating when and if the interaction between two macromolecules at the molecular dynamics level can be approximated at the mesoscopic level as described by the Smoluchowski,Collins,Kimball & Berg theory.


The lac Repressor Displays Facilitated Diffusion in Living Cells, Petter Hammar, Prune Leroy, Anel Mahmutovic, Erik G. Marklund, Otto G. Berg, Johan Elf*, Science 336, 1595 (2012)